Has PHARLAP run its race? Where to now for open lung ventilation strategies in ARDS?

While high PEEP, low tidal volume, pressure limited ventilation is well established in the management of ARDS patients, a range of open lung strategies are variably used and of unproven value.

The ANZICS CTG endorsed PHARLAP trial set out to explore a protocolised set of these interventions.

Sadly PHARLAP has run into a hurdle.

So has it run its race?  Or is there still more to the open lung story?

Primary investigator for the PHARLAP trial, Carol Hodgson of the ANZICS Research Centre, joined me to chat about PHARLAP at the 2018 ANZICS Clinical Trials Group meeting in Noosa

Listen to the podcast here